Gregory Bateson (1904–80).

His allegory describes a fantastic horse developed
by the sharpest minds in genetics, the polyploid horse. This horse was
twice as long, twice as wide and twice as tall as a normal horse.
Of course, its weight was eight times that of an ordinary horse. It
was unable to support its own weight in an upright position, for its
skeleton was only four times as thick as that of an ordinary horse.
The inner organs were continually on the verge of being cooked,
since its skin was twice as thick, while the surface area was only four
times that of an ordinary horse. It was also chronically hungry and
had difficulty breathing, since the oesophagus and windpipe were
only four times the size of those of an ordinary horse, while the body
was eight times as heavy

(Tyranny of the moment, Thomas Hylland Eriksen)